There are reports that RBCs can synthesize nitric oxide.Their communications and interactions are wide-scoped with endothelial cells (as in sickle cell patients), platelets (clotting cells), macrophages (a type of white blood cells), and even bacteria via membrane proteins.įigure 4: Interaction of RBCs in sickle cell anemia.The production of human red blood cells in adults is estimated to be approximately 2,400,000 new cells per second.Their average lifespan is 100-120 days (nearly 3.5-4 months).There are several changes (especially morphological) that cumulatively give rise to mature erythrocytes.įigure 3: We can notice the myeloid origin or erythrocytes in the flowchart. So, erythrocytes are “ myeloid in origin” or belong to the myeloid series of blood cells. The process of production of erythrocytes is called “erythropoiesis” and takes place as HSCs give rise to myeloid progenitors or erythrocyte precursors. They are produced specifically in the red bone marrow (BM) from hematopoietic stem cells (HSCs).Their physiology supports oxygen transport throughout the human body tissues.They are devoid of the ability to divide and form new erythrocytes. This modality in the structure supports the maximization of space in the erythrocytes for the accommodation of hemoglobin molecules.įigure 2: Structure of RBCs as observed under 3 different types of microscope.
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